Location: US 49E and MS 12, Tchula Reassurance shield as 12 joins 49E. Location: US 49E and MS 12, Holmes Cty A couple miles later we’ll approach the 12 split. Location: US 49E and MS 12, Holmes Cty Turn right to stay on 12 west. Location: US 49E and MS 12, Holmes Cty Follow 12 … Continue reading U.S. Route 49E, MS-12 to MS-12